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Lb Pharmaceuticals, Inc.

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LB Pharmaceuticals Inc. Market Research Report



Company Overview



- Name: LB Pharmaceuticals Inc.
- Mission: To develop novel therapies that improve patient outcomes and address significant unmet medical needs in neuropsychiatric disorders.
- Founded: 2015
- Founders: No information is available
- Key People:
- Zachary Prensky: Chief Executive Officer
- Andrew Vaino: Chief Scientific Officer
- Roger Sawhney: Chief Financial Officer
- Anna Eramo: Chief Medical Officer
- Scott Garland: Chairman of the Board of Directors
- Dr. Robert Ruffolo: Independent Director
- Ran Nussbaum: Managing Partner and Co-Founder, Pontifax
- Rebecca Luse: Principal, Deep Track Capital, LP
- Dr. Rajul Jain: Managing Director, Vida Ventures
- Dr. Chen Yu: Founder and Managing Partner, TCGX
- Location: 575 Madison Avenue, New York, NY 10022
- Number of Employees: No information is available
- Revenue: No information is available
- Known For: Developing novel, patent-protected therapies for neuropsychiatric diseases including schizophrenia.

Products



LB-102



- Description: LB-102 is a novel, patent-protected methylated derivative of amisulpride, aimed to improve its therapeutic profile.
- Key Features:
- Improved Dosing and Safety: Achieves dopamine receptor occupancy in the brain comparable to amisulpride at significantly lower doses, resulting in potential safety improvements.
- Tolerability: LB-102 is well-tolerated and potentially offers longer-term efficacy improvements.
- Receptor Binding: Similar to amisulpride, LB-102 has low binding to 5-HT2C, Alpha-1, or H1 receptors, potentially reducing side effects like anti-cholinergic effects, weight gain, and sedation.
- Once-Daily Dosing: LB-102 is being developed for once-daily dosing, making it easier for patients to adhere to their treatment plans.
- Potential for Broader Efficacy: Aims to be more effective and better tolerated than most existing first-line treatments for schizophrenia, especially in addressing positive, negative, and cognitive symptoms.

Recent Developments



Recent Developments


- Clinical Trials: Currently conducting a Phase 2 clinical trial (NCT06179108) to test LB-102 in patients with acute schizophrenia, evaluating its efficacy and safety.
- Partnerships: No information is available
- New Features Added:
- Clinical studies have demonstrated that LB-102 achieves prolonged dopamine receptor engagement.
- Clinical data shows superior dopamine receptor occupancy and improved efficacy at lower doses compared to amisulpride.

Publications and Presentations


- ASCP 2024: "LB-102, a novel benzamide for the treatment of schizophrenia: safety and dopamine receptor occupancy data from two clinical studies."
- Springer Nature Psychopharmacology, July 2022: "A randomized, double‑blind, placebo controlled, phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of LB‑102."
- ACNP 2021: "PET clinical study of novel antipsychotic LB-102 demonstrates unexpectedly prolonged dopamine receptor engagement."
- ECNP 2021: "LB-102 displays superior dopamine receptor occupancy compared to amisulpride in mouse and human PET studies."
- ECNP 2020: "Safety, pharmacokinetics, and pharmacodynamics of LB-102, a selective D2/5-HT7 antagonist, in healthy volunteers."
- ECNP 2019: "Building a translational bridge from animals to man for clinical candidate LB-102, a next-generation benzamide antipsychotic."
- ACS Omega 2019: "Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5‑HT7."
- ECNP 2018: "LB-102, Potential Schizophrenia Treatment, Displays Polypharmacology as a Racemate—S Enantiomer Binds D2 Receptors and R Binds 5-HT7Receptor."
- SOBP May 2018: "Establishing a PK-PD-E Relationship for Clinical Candidate LB-102, a Next-Generation Benzamide Antipsychotic."
- ECNP Sept 2017: "Pre-clinical Evaluation of Two Novel Benzamides LB-102 and 103 for the Treatment of Schizophrenia."

Contact Information


- Address: 575 Madison Avenue, New York, NY 10022
- Phone Number: 646-588-8175
- Website: No information is available

No information is available for several fields, but those which were provided have been thoroughly incorporated into this detailed report.