Vineeth Surendranath

Summary

My current project involves the development of analysis workflows for a novel approach for diagnostics of Measurable Residual Disease for Acute Lymphoblastic Leukemia using both short read and long read technologies. This workflow has been granted a patent now by the European Patent Office. I have experience in Genotyping and the leveraging of full length sequencing toward this goal particularly using the Oxford Nanopore Technology platform. I focussed on algorithmic developments for accurate full-length genotyping of the HLA loci and other loci such as KIR focused on stem cell transplantations; secondary to this, I also explore solutions for high throughput real-time data analysis in the order of tens of thousands of samples every day that come in for processing at the DKMS Life Science Lab which forms the largest donor repository in Germany. I have previously worked on various aspects of gene expression regulation, particularly in the context of developmental systems and their evolution. My focus was on using Second Generation Sequencing (Deep Sequencing) tools to look at the heterogeneity of the 3' untranslated regions in the developing embryo, and in disease systems. This involved analysing large sets of genomics data, and in this context, the visualisation of data is a strong area of interest, both interactive and static. Serendipity brought specialty coffee into my life, and I have gone from just enjoying specialty coffee to be skilled in making it and managed a cafe for nearly a decade. Moonlighting in specialty coffee provided a contrasting and interesting experience to research, and it was fascinating to see how precision and flexibility plays a challenging role in both. I have experiences in working as part of a large research group and medium-sized consortium projects. I particularly enjoy collaborative projects that are strongly at the interface of experimental Biology and theoretical approaches leveraging Mathematics and Computer Science. I have also supervised a number of students toward their thesis projects as part of their Master's thesis.